Validation of fumonisin biomarkers in F344 rats
نویسندگان
چکیده
منابع مشابه
Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.
Fumonisin B1 (FB1) is a mycotoxin isolated from Fusarium fungi that contaminate crops worldwide. A previous study demonstrated that FB1 promoted preneoplastic foci in initiated rats and induced hepatocellular carcinomas in BD IX rats at 50 parts per million (ppm), but fundamental dose-response data were not available to assist in setting regulatory guidelines for this mycotoxin. To provide this...
متن کاملCalcium montmorillonite clay reduces urinary biomarkers of fumonisin B₁ exposure in rats and humans.
Fumonisin B₁ (FB₁) is often a co-contaminant with aflatoxin (AF) in grains and may enhance AF's carcinogenicity by acting as a cancer promoter. Calcium montmorillonite (i.e. NovaSil, NS) is a possible dietary intervention to help decrease chronic aflatoxin exposure where populations are at risk. Previous studies show that an oral dose of NS clay was able to reduce AF exposure in a Ghanaian popu...
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15 صفحه اولMetabolism of (R)-(+)-pulegone in F344 rats.
(R)-(+)-Pulegone, a monoterpene ketone, is a major component of pennyroyal oil. Ingestion of high doses of pennyroyal oil has caused severe toxicity and occasionally death. Studies have shown that metabolites of pulegone were responsible for the toxicity. Previous metabolism studies have used high, near lethal doses and isolation and analysis techniques that may cause degradation of some metabo...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2007
ISSN: 0041-008X
DOI: 10.1016/j.taap.2007.06.027